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The 18-year-old beauty - who is the younger sister of Kim Kardashian - shut down rumours of a romance when she attended the American Music Awards on Sunday night (24.11.13), where Harry had also been performing with One Direction.
She told E! News: ''[There is] No story. We're friends. He's cool, yeah, he's cool.''
Kendall split from her high-school boyfriend Julian Brooks earlier this year, before hitting-out at reports she was dating 21-year-old rapper Young Jinsu last month - but she has insisted it's difficult to have male friends.
She added: ''You go out with one person, you're automatically dating them.''
Kendall's 16-year-old sister Kylie - who is also speculated to be dating Jaden Smith - was quick to defend her sibling, as she explained: ''It's very hard to have friends of the opposite sex''
The comments come after Harry - who split with Taylor Swift in January before being linked to Cara Delevingne - insisted he wasn't dating the reality star.
Asked by Piers Morgan on 1D Live - the band's seven-hour live streaming event on Saturday (23.11.13) he explained: ''We went out for dinner, but no, I guess. I don't know.''