seth rogen 50/50 trailer seth rogen 50/50 trailer. Starring: Joseph Gordon-Levitt, Seth Rogen, Anna Kendrick, Bryce Dallas Howard, Anjelica Huston. Release Date: September 30, 2011. Synopsis: Inspired by personal experiences, 50/50 is an original story about friendship, love, survival and finding humor in unlikely places. Joseph Gordon-Levitt and Seth Rogen star as best friends whose lives are changed by a cancer diagnosis. Rogen also serves as producer, along with Evan Goldberg and Ben Karlin. Jonathan Levine directs from a script by Will Reiser. "We worked with Will on Da Ali G show, and it was shortly after that we learned he was sick." Rogen recalls. "As shocking, sad, confusing and generally screwed up as it was; we couldn't ignore that because we were so ill-equipped to deal with the situation, funny things kept happening. Will got better, and when he did, we thought the best way to pull something good out of the situation was to get him to write a screenplay. ...